Coenzyme Q10 kuphela kwe-coenzyme Q emzimbeni womntu, ekwabizwa ngokuba yi-ubiquinone. I-Coenzyme Q10 ibonakaliswe ukuba ine-antioxidant, i-radical scavenging yamahhala, i-anti-tumor kunye nokuphucula iziphumo zokugonywa komntu, ngaloo ndlela ikhulula ukudinwa kunye nokuphucula umthamo wokuzilolonga, kunye nokuchasana nokuguga. Kwaye iziphumo ezahlukeneyo zempilo ezifana nokukhuselwa kwentliziyo.
Nye,Imisebenzi ye-Physiological ye-coenzyme Q10
1. I-free radical scavenging kunye nomsebenzi we-antioxidant (ukulibazisa ukuguga kunyebuhle)
I-Coenzyme Q10 ikhona kumazwe amabini: iyancipha kwaye i-oxidized. Phakathi kwabo, i-coenzyme Q10 eyancitshisiweyo i-oxidized ngokulula kwaye inokuthintela i-peroxidation ye-lipids kunye neeprotheni kunye ne-scavenge radicals yamahhala. Ukunciphisa uxinzelelo lwe-oxidative, oluyimpembelelo embi eveliswa ngama-radicals amahhala emzimbeni kwaye yinto ebalulekileyo ekhokelela ekugugeni kunye nezifo. I-Coenzyme Q10 yi-antioxidant esebenzayo kunye ne-free radical scavenger enokucothisa umonakalo obangelwa luxinzelelo lwe-oxidative.Coenzyme Q10 inokuphucula i-bioavailability yolusu, ilungise ulusu, inyuse ukuxinana kweekeratinocytes, iphucule amandla e-antioxidant kwiiseli zolusu, inqanda ukuguga kwesikhumba, kwaye ifezekise ifuthe lonyango kwi-dermatitis, i-acne, i-bedsores, izilonda zolusu kunye nezinye izifo zolusu. I-Coenzyme Q10 inokukhuthaza ukubunjwa kweeseli ze-epithelial kunye ne-benigization yezicubu ze-granulation, ukuthintela ukubunjwa kwe-scar, kunye nokukhuthaza ukulungiswa kwesikhumba; inqanda umsebenzi we-phosphotyrosinase, ukukhusela ukubunjwa kwe-melanin kunye namabala amnyama; ukunciphisa ubunzulu bemibimbi, ukuphucula ulusu; kwaye inokunyusa ukungafihli Ukuxinwa kwe-amino acids kwandisa ukufuma kwesikhumba; inefuthe elihle ekuphuculeni ithoni yesikhumba esithambileyo, ukunciphisa imibimbi, kunye nokubuyisela ukuguda kwasekuqaleni kolusu, ukuqina kunye neempawu zokuthambisa.
2. Ukuphucula ukukhuseleka komntu kunye ne-anti-tumor
Kwangoko ngo-1970, izifundo ezifanelekileyo zichaze ukuba ukuthatha i-coenzyme Q10 kwiimpuku kunokunyusa umsebenzi weeseli zomzimba zokuzivikela ekubulaleni ibhaktheriya, ukuphucula iimpendulo ze-antibody, kunye nokukhuthaza ukwanda kwenani le-immunoglobulins kunye ne-antibodies. UNikbakht et al. Ufunde ukuba xa iimbaleki zamadoda zithatha iCoenzyme Q10 emva kokhuphiswano olulandelelanayo, inani le-neutrophils kwiplasma yabo lancitshiswa kakhulu. Ke ngoko, bakholelwa ukuba iCoenzyme Q10 iluncedo ekukhuseleni amajoni omzimba kunye nokuphucula ukhuseleko lomzimba. Kubantu abaqhelekileyo, ukuthatha iCoenzyme Q10 ngomlomo emva kokusebenza kakhulu kunokuphucula ukudinwa komzimba kunye nokuphucula amandla omzimba.
Uphando kule minyaka yakutsha nje lubonise ukuba i-coenzyme Q10, njengesixhasi somzimba esingangqalanga, inokudlala indima entle ekuphuculeni ukhuselo lomzimba kunye ne-anti-tumor, kwaye inesiphumo esithile sekliniki kumhlaza we-metastatic ophambili.
3. Yomeleza amandla entliziyo kwaye wongeze amandla engqondo
ICoenzyme Q10 yenye yezona zinto zibalulekileyo kumzimba womntu. Umxholo wayo uphezulu kakhulu kwi-myocardium. Xa ingekho, iya kubangela ukungonelanga ukusebenza kwentliziyo, ibangele ukungahambi kakuhle kwegazi, ukunciphisa amandla okusebenza kwentliziyo, kwaye ekugqibeleni ikhokelele kwisifo sentliziyo. Iziphumo eziphambili ze-coenzyme Q10 kwi-myocardium kukukhuthaza i-phosphorylation ye-cellular oxidative, ukuphucula i-metabolism yamandla e-myocardial, ukunciphisa umonakalo we-ischemia kwi-myocardium, ukwandisa ukuphuma kwegazi lentliziyo, ukuphucula ukuxinana okungapheliyo kunye nokuxhathisa i-arrhythmias, ngaloo ndlela ikhusela i-myocardium. Ukuphucula ukusebenza kwentliziyo kunye nokubonelela ngamandla okwaneleyo kwi-myocardium. Izifundo zeklinikhi zibonisa ukuba ngaphezu kwe-75% yezigulane zesifo senhliziyo ziye zaphucula kakhulu imeko yazo emva kokuthatha iCoenzyme Q10. I-Coenzyme Q10 i-activator ye-metabolic enokuthi isebenze ukuphefumla kweselula, inike i-oksijini eyaneleyo kunye namandla kwi-cardiomyocytes kunye neeseli zengqondo, zigcine iiseli zikwisimo esihle kunye nempilo, kwaye ngoko kuthintela iziganeko zentliziyo kunye ne-cerebrovascular.
4. Ukulawula i-lipids yegazi
Ngelixa ukwehlisa i-lipids yegazi, i-statins iphinda ithintele ukuzimela komzimba kwi-coenzyme Q10. Ke ngoko, abantu abane-lipids ephezulu yegazi kufuneka bathathe i-coenzyme Q10 xa bethatha i-statins ukufezekisa isiphumo esingcono sokwehlisa i-lipid. I-Coenzyme Q10 inokunciphisa umxholo we-low-density lipoprotein eyingozi kumzimba womntu, inqande i-lipoprotein ephantsi-density ukuba ingangeni kwi-gap cell endothelial, ukunciphisa ukubunjwa kwe-lipids kudonga lwangaphakathi lwe-arteries, kunye nokuthintela i-lipids ekwenzeni i-atherosclerotic. amacwecwe kwi-intima yemithambo yegazi. , ngelixa ukwandisa umsebenzi we-high-density lipoprotein, ukususa ngokukhawuleza inkunkuma, i-toxins kunye namacwecwe akhiwe eludongeni lwangaphakathi lwemithambo yegazi, ukulawula i-lipids yegazi kunye nokuthintela ukubunjwa kwe-atherosclerosis.
Mbini, Ukhuseleko lweCoenzyme Q10
Umzimba womntu awunawo amanqanaba aphezulu eCoenzyme Q10 ekuzalweni, kodwa umxholo ufikelela kwincopho yayo malunga ne-20 yobudala. Emva kweminyaka engama-25, ukukwazi ukudibanisa iCoenzyme Q10 kuncipha ngokuthe ngcembe. Njengoko iminyaka ikhula, iCoenzyme Q10 kumalungu ahlukeneyo kunye nezicubu emzimbeni iyancipha ngokuthe ngcembe, kwaye iCoenzyme Q10 entliziyweni iyancipha ngakumbi. Xa umxholo weCoenzyme Q10 emzimbeni womntu uyancipha nge-25% Kwixesha elizayo, izifo ezahlukahlukeneyo ziya kwenzeka, ngoko ke ukuxhaswa kwangaphandle kweCoenzyme Q10 kubaluleke kakhulu. Into ephawulekayo yeCoenzyme Q10 kukuba ayinayo ityhefu, ayinayo i-teratogenic kwaye ayinayo imiphumo ecacileyo, kwaye ikhuselekile kakhulu ekusebenziseni iklinikhi. I-Coenzyme Q10, njengenye yezona zinto zibalulekileyo kwi-coenzymes emzimbeni womntu, isetyenziswa ngokubanzi kukhathalelo lwezonyango.
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