Ikakhulu isebenza malunga neSpermidine kunye neSpermidine trihydrochloridecan kuphando

Isebenza ikakhulu malungaI-Spermidine kwayeI-Spermidine trihydrochlorideunako kuphando

I-Spermidine [N- (3-aminopropyl) -1,4-diaminobutane] i-saturated linear triamine idla ngokuhlelwa njengephakathi kwi-synthesis ye-spermine. Ine-molecular formula C1H19N3 kunye ne-molar mass 145.25 g / mol kwaye incinci, i-soluble yamanzi, i-amphiphilic molecule enekhono lokungena kwi-biological membranes. Kwenzeka kuzo zonke izinto eziphilayo, kungakhathaliseki ukuhlelwa kwetaxonomic.

I-Spermidine inokubophelela kwiindidi ezininzi ezahlukeneyo zeamolekyu, ezenza zibe luncedo kakhulu. Baxhasa iinkqubo ezibandakanya ukukhula kweeseli, ukuzinza kweDNA, ukwanda kweeseli kunye ne-apoptosis. Kubonakala ngathi iipolyamines zisebenza ngendlela efanayo kwizinto zokukhula ngexesha lokwahlulwa kweeseli. Yingakho i-spermidine ibalulekile ekukhuleni kwezicubu ezinempilo kunye nomsebenzi.

I-1.Iipropati ezichasayo ze-Spermidine zomhlaza kunye nempilo ye-cardiovascular

Kuphononongo lwe-2016, i-spermidine yafunyanwa ukuguqula iwashi yokuguga kunye nokuphucula umsebenzi we-cardiovascular kumagundane asebekhulile. Kwinqanaba le-organ, isakhiwo senhliziyo kunye nomsebenzi ophuculweyo kwiigundane ezikhulileyo ezinikwe i-spermidine. I-Metabolism nayo yaphuculwa kwezi mpuku ngenxa yokubuyiselwa kwesakhiwo se-mitochondrial kunye nomsebenzi emva kokuxhaswa kwe-spermidine.

2. I-Spermidineesebenza njengomchasi-ukwaluphala izithako

Ngokubhekiselele kubomi obude, izifundo ezininzi zezilwanyana zibonise ukuba ukuthatha i-spermidine kwandisa ixesha lokuphila kwaye kuthintele i-fibrosis yesibindi kunye ne-hepatocellular carcinoma. Okufanayo kubonakala kuyinyaniso kwizidlo ezityebileyo ze-polyamine. Kukho nobungqina bokuba kwandisa ukuchasana noxinzelelo, kwaye ukuhla okuhambelana neminyaka kwi-spermidine kuxhasa ukuphuhliswa kwezifo ezinxulumene neminyaka.

3.Spermidine trihydrochlorideunako rfundisa iCognitive Decline

Uphando olupapashwe kwijenali yeeNgxelo zeSeli ngo-2021 iinkcukacha zokuba i-spermidine yokutya iphucula ukuqonda kunye nokusebenza kwe-mitochondrial kwiimpukane kunye neempuku, kwaye ibonelela ngedatha yabantu abanokubakho.