Intshayelelo ye-NAD Pre-Cursor

I-NAD + yi-coenzyme ebalulekileyo, egama layo elipheleleyo yi-nicotinamide adenine dinucleotide. Ikho ngokubanzi ngaphakathi kweeseli kwaye ithatha inxaxheba kwiimpendulo ezininzi ezibalulekileyo ze-biochemical. I-NAD+ idlala indima ephambili kwiinkqubo ezininzi zebhayoloji, kubandakanya amandla e-metabolism, ukuphefumla kweselula, ukulungiswa kwe-DNA, ukukhutshelwa kofuzo, kunye nokuguga. Iyakwazi ukufumana okanye ukukhulula ii-electron kuyo ngeendlela ezahlukeneyo ze-biocatalytic reactions. Kule nkqubo, iimpendulo ezinokuthi i-NAD + ifake i-catalyze ziquka i-redox, ukunciphisa i-carbonyl, ukuhanjiswa kwe-acyl, njl. Njenge-coenzyme, umsebenzi oyintloko we-NAD + kukudlulisa i-electron kunye ne-hydrogen ions kwi-enzyme-catalyzed reactions. Ngexesha lale nkqubo, i-NAD+ iyancitshiswa ibe yi-NADH, ngaloo ndlela ibonelela ngee-electron kunye nee-ion ze-hydrogen kwezinye ii-enzame reactions ezifunekayo. I-NAD+ ikwatsale umdla wenzululwazi kwiminyaka yakutshanje kuba kucingelwa ukuba ibandakanyeka kwinkqubo yokwaluphala. Izifundo ziye zafumanisa ukuba ngexesha lokuguga, inqanaba le-NAD + kwiiseli liyancipha, kwaye ukongeza i-NAD + kunokukhuthaza i-metabolism yamandla eselula, ukulungiswa kwe-DNA kunye nokulibaziseka ukuguga. Ukongeza, i-NAD + ifunyenwe idlala indima ebalulekileyo ekulungiseni umonakalo we-DNA, i-apoptosis, i-enzymes esebenzayo kunye nokulawula ukubonakaliswa kwemfuza. Okwangoku, abantu benza uphando olunzulu nge-NAD+ kunye nendima yayo kwi-physiology kunye ne-pathology, ukuze bafumane ngakumbi malunga nemisebenzi kunye nokusetyenziswa kwe-NAD+.