Ethetha ngayoiberberine , wonke umntu usenokuba akaqhelanga kangako, kodwa wonke umntu umele azi intetho eqhelekileyo ethi: Umntu osisimumu utya icoptis – akakwazi ukuyixela intlungu! Kunjalo, eyona nxalenye ikrakra kwicoptis yiberberine, eyiberberine hydrochloride.
I-Berberine (BBR) yi-alkaloid ye-isoquinoline - i-C20H19NO5 ekhutshwe kwi-Coptis chinensis. Ikhona kwizityalo ze 10 genera kunye 4 iintsapho kuquka Berberidaceae. Iikristale ezityheli ezimile okwenaliti zinokuvuthwa ukusuka kwi-diethyl ether, nendawo yokunyibilika eyi-145°C. Ziyanyibilika emanzini kwaye azinyibiliki kwi-benzene, i-diethyl ether kunye ne-chloroform.
Uphando lwanamhlanje lwe-pharmacological luqinisekisile ukuba i-berberine inokusilela okukhulu kwentliziyo, i-anti-arrhythmia, i-cholesterol ephantsi, i-anti-vascular smooth muscle proliferation, ukuphucula ukuxhathisa kwe-insulin, i-anti-platelet, i-anti-inflammatory kunye nezinye iziphumo. Ngoko ke, kunokuba luncedo kwi-cardiovascular and nervous system izifo. Ukusetyenziswa kwayo okubanzi kunye nokubalulekileyo okulindelweyo kuye kwatsala umdla okhulayo. Ngokutsho kophando lwamva nje lweklinikhi, i-berberine ineziphumo ezilungileyo ekuthinteleni nasekuphatheni uxinzelelo lwegazi, i-hyperlipidemia, isifo seswekile, i-arrhythmia, amathumba kunye nezinye izifo. I-Berberine hydrochloride iye yaxelwa kakhulu ekunciphiseni i-lipids yegazi. I-BBR inokulawula ukubonakaliswa kwe-low-density lipoprotein receptor LDLR kwaye ikhuthaze ukufunxwa kweprotheni ye-LDL ngamaseli esibindi. I-BBR iguqulwa ibe yi-dihydroberberine (dhBBR) nge-nitroreductase ye-intestinal flora gut microbiota, eyenza ukuba ifunnwe lula ngamathumbu. Emva kokufunxa, i-oxidized kwi-BBR kwizicubu zamathumbu kwaye ingene egazini. Ukufezekisa i-lipid-ukwehlisa kunye nemiphumo ye-hypoglycemic. I-BBR inokuphucula imetabolism yamandla. Ukulawulwa komlomo kwe-BBR kukhuthaza i-gut microbiota ukuvelisa i-butyrate, engena egazini kwaye isebenze kwi-SCFAs (i-short chain fatty acids), ukunciphisa i-lipids yegazi kunye namanqanaba eswekile yegazi.
I-BBR inokukhuthaza ukuvuselelwa kweeseli ze-pancreatic islet kwaye ineenzuzo ezininzi kunezinye iziyobisi ezichasene nesifo seswekile. Izilingo zeklinikhi ezifanelekileyo zibonise ukuba i-berberine inokuthintela i-myocardial fibrosis kwiigundane zesifo seswekile; I-BBR ineempembelelo ze-anti-platelet, inokunyusa umxholo we-nucleotide kwiiplatelet kwaye inhibit aggregation. I-Berberine idibene ne-statins idlala indima ebalulekileyo ekuzinziseni i-plasma trimethylamine oxidation kwi-coronary heart disease kunye nokuvimbela ukubunjwa kwe-atherosclerosis.
Iberberine yaseTshayina yeyona ndlela ifanelekileyo kumachiza e "statin". Ekubeni i-berberine inamaxesha amaninzi aphantsi kunamachiza "e-statins", ukufunyanwa kwempembelelo ye-berberine yokunciphisa igazi-lipid kunexabiso elingalindelekanga lothintelo kunye nonyango lwe-hyperlipidemia, isifo seswekile kunye nesifo senhliziyo.
【Qhagamshelana nathi】
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Ixesha lokuposa: Jan-08-2024
