Ukongeza kutshintsho lwendlela yokuphila kunye nokubambelela kwimikhwa elungileyo, ukongezwa kwangaphandle kwezinto zendalo ezichasene nokwaluphala kukwayindlela elula nelula yokuchasa ukuguga. Ngokolwalathiso lophando (NAD + metabolic regulation) kunye neziphumo zophando lwangoku lokulwa nokuguga kunye nezicelo ezixhalabileyo.nayo i"inkungu yengqondo"emva kwe-COVID-19,thina'ndingathanda ukwazisa ezininzi ezilungileyoizithako ezichasene nokugugaukusuka kwezongezo zokuthengisa ezishushu kwiAmazon.
1. izongezo zeNAD+ (NMN, NR, NADH)
Amanqanaba e-NAD + ehla ngokukhula, okukhokelela ekuwohlokeni okunovelwano kumanqanaba e-NAD +. Intsapho ye-acetylase (i-sirtuins, edla ngokubhengezwa njengeeprotheni zexesha elide) ayikwazi ukugcina umsebenzi oqhelekileyo, ukwenzela ukuba imisebenzi emininzi enenzuzo kwimpilo edibeneyo ngama-sirtuin ayinakwenziwa, enye yezizathu ezibalulekileyo zokuguga.Ii-ntake ye-NMN (nicotinamide mononucleotide), i-NR (i-nicotinamide riboside) okanye i-NADH (i-nicotinamide adenine dinucleotide) inokunceda iiseli zonyuse amanqanaba e-NAD+, kwaye ezi zikhona ngokwendalo kwiiseli kunye nokutya kwendalo..Okwangoku, kukho amakhulu ezifundo zeklinikhi kwi-NMN, NR, kunye ne-NADH, egxile kwimiba eyahlukeneyo efana nokuchasana nokuguga, isifo seswekile, imetabolism, kunye nokuqonda.
2. I-Pyrroloquinoline quinone (PQQ)
I-PQQ yi-redox coenzyme kunye ne-antioxidant eyomeleleyo. Ikwakho nasekutyeni okwahlukeneyo. Umxholo wePQQ kumzimba womntu uphantsi kakhulu. I-PQQ kwiiseli zomntu inokuphuma ekutyeni okanye kwii-microorganisms. Ukutya okune-PQQ eninzi kubandakanya: i-natto, i-parsley, iti eluhlaza, iziqhamo ze-kiwi, i-papaya, i-tofu, njl. njl. Iingenelo zempilo ezinokubakho ze-PQQ zibandakanya: ukuphucula ukulala, ukulwa nesifo seswekile, i-anti-arthritis, i-anti-osteoporosis, ukunciphisa ukulimala kwe-cardiac ischemia-reperfusion, inhibiting tyrosinase, ukuphucula ukuchuma.
3. Fisetin
Fisetin, eyaziwa ngokubaMsi Tree Extract , i-flavonol ephuma kwisityalo kunye ne-pigment yesityalo esiqhelekileyo esifumaneka kwimifuno emininzi eqhelekileyo kunye neziqhamo ezifana ne-strawberries, ii-apula, i-persimmons, i-anyanisi kunye namakhukhamba. Yandisa ubomi beegundane ezikhulileyo nge-10%, inciphisa iimpawu zokuguga kwiithishu, kwaye iyancipha izifo ezinxulumene nokuguga. I-anti-aging mechanism ye-fisetin kukuba inokususa iiseli ze-senescent kwaye isebenze njenge-synolytic. Ukuqokelelana kweeseli ze-senescent kukwangunobangela obalulekileyo wokuguga kunye nezifo ezinxulumene nokuguga. Uphononongo lufumene ukuba uncedo olunokwenzeka lwezempilo lwe-fisetin lubandakanya: i-anti-oxidation, i-anti-inflammation, ukukhuselwa kwentliziyo, ukukhuselwa kwengqondo, ukuthintela ukukhuluphala kunye nokuphazamiseka kwe-metabolic.
4. Urolithin A
I-Urolithin A iqulethwe kwizicubu ezahlukeneyo zomzimba womntu. Kodwa i-urolithin A ayisiyo molekyuli yendalo ekutyeni kwaye iveliswa ngamanye amathumbu ebhaktheriya asebenzisa i-ellagic acid kunye ne-ellagitannins. I-precursors ye-urolithin A - i-ellagic acid kunye ne-ellagitannins-ifumaneka ngokubanzi kwizidlo ezahlukahlukeneyo, ezifana neerharnati, i-strawberries, i-raspberries kunye ne-walnuts. Ingaba umzimba womntu unokuvelisa i-urolithin A eyaneleyo emva kokungena ezi zinto zangaphambili nazo zikhawulelwe yiyantlukwano ye-microorganisms yamathumbu. Ukuguga kukhokelela ekunciphiseni amandla e-autophagic yeeseli, nto leyo ekhokelela ekuqokeleleni kwe-mitochondria eyonakalisiweyo, ivelise uxinzelelo lwe-oxidative, kwaye ikhuthaze ukudumba. I-Urolithin A iphucula impilo ye-mitochondrial ngokunyusa i-autophagy.
5. I-Spermidine
I-Spermidine i-polyamine yendalo i-concentration yayo ye-intracellular iyancipha ngexesha lokuguga kubantu, kwaye kunokubakho unxibelelwano phakathi kokunciphisa ukuxinwa kwe-spermidine kunye nokuguqulwa kweminyaka. .Imiphumo enokubakho ye-spermidine ibandakanya: ukunciphisa uxinzelelo lwegazi, ukunyusa ukukhusela i-antioxidant, ukwandisa i-arginine bioavailability, ukunciphisa ukuvuvukala, ukunciphisa ukuqina kwe-vascular, ukulawula ukukhula kweeseli.
Ixesha lokuposa: Mar-02-2023
