Lo Han Guoisicatshulwa ngumgubo omthubi ophaphathekileyo ukuya kwisicatshulwa esimdaka. Inencasa eswiti kakhulu, 240 amaxesha amnandi kunesucrose, kufutshane neswekile, kunye nencasa kancinane efana ne-licorice. Indawo yokunyibilika ye-high-purity mogroside yi-197-201 ° C. Inyibilika ngokulula emanzini nakwi-ethanol.
Umsebenzi:
1.Monk Fruit Extract(Mogroside) isetyenziswa kumayeza emveli aseTshayina kwingqele, ukhohlokhohlo, umqala obuhlungu, ukungakhululeki kwesisu, kwaye ingasetyenziselwa ukucoca igazi.
2. I-Monk Fruit Extract (i-Mogroside) iyanyibilika ngokulula emanzini kwaye ayinayo imvula.
3. I-Mogroside iqulethe isixa esikhulu se-amino acids, i-fructose, iivithamini kunye neemaminerali. Ikwasetyenziswa ekuphekeni kwemveli yaseTshayina njengesiqholo kunye nesongezo sesondlo. Njengesimuncumuncu sendalo iphela, yeyona ndawo ifanelekileyo yokuthatha indawo yezimuncumuncu ezenziweyo njenge aspartame. Ingasetyenziselwa iziselo, izinto ezibhakiweyo, ukutya okunesondlo, ukutya okunekhalori ephantsi okanye okunye ukutya okudinga i-carbohydrates sweeteners ephantsi okanye engenazo okanye iikhalori eziphantsi okanye ezingenazo. Ukupheka okanye ukubhaka akuchaphazeli incasa okanye ubumnandi bayo.
Iziphumo ze-Pharmacological
(1) Impembelelo ye-Expectorant: i-Mogroside (i-glycosides iyonke> 80%) i-0.2g / kg, i-0.4g / kg, i-0.8g / kg ilawulwa nge-intragastically. Iidosi ze-0.4g / kg kunye ne-0.8g / kg zandisa kakhulu ubuninzi beemfihlo ze-tracheal kwiigundane, ezibonisa umphumo obalulekileyo we-expectorant.
(2) I-Lung-clearing kunye ne-antitussive effect: i-Mogroside (i-glycosides iyonke> 80%) 0.2g/kg, 0.4g/kg, 0.8g/kg yanciphisa kakhulu inani lokukhohlela kwiimpuku ezibangelwa yi-ammonia, kodwa ayizange ibe nempembelelo ebalulekileyo ixesha lokufukamela ukhohlokhohlo olubangelwa yi-ammonia.
(3) Ukukrazula okukhulu kunye neziphumo ze-antioxidant:
a.Isicatshulwa seMogroside(i-Mogroside) (i-glycosides iyonke ≥ 98%, umxholo we-Mogroside V i-65.20%) inomphumo othile wokuhlambalaza kwi-hydroxyl free radicals kunye ne-superoxide anion free radicals. Ngokunyuka koxinaniso lwesicatshulwa seMogroside, umphumo wokulahla ukhula ngokuthe ngcembe, ubonisa ubudlelwane obuthile be-dose-effect;
b. Isicatshulwa se-Mogroside sinempembelelo ebalulekileyo yokuthintela kwi-oxidative hemolysis reaction ye-RBC yegundane ngexesha lokufukanyelwa kwe-in vitro. Kuluhlu lwe-0.04-1.15 mg / ml, izinga lokuvimbela i-Mogroside extract kwi-erythrocyte autooxidative hemolysis ingaphezulu kwe-50%, kwaye i-extract ye-Mogroside inefuthe elihle lokukhusela kwi-RBC autooxidative hemolysis;
c. Impembelelo yokukhusela ye-Mogroside extract kwi-RBC autooxidative hemolysis ayibonisi ubudlelwane be-dose-effect. I-dose engcono kakhulu yi-0.46 mg / ml, enezinga lokuvimbela i-85.55%;
d. I-Malondialdehyde (MDA) yimveliso yokugqibela ye-lipid peroxidation kwaye ingasetyenziselwa ukuvavanya amandla e-lipid peroxidation. I-extract ye-Mogroside inempembelelo enamandla yokuthintela kwimveliso ye-MDA ngexesha le-rat erythrocyte autooxidation hemolysis;
kwaye.Isicatshulwa seMogrosideinesiphumo esihle sokuthintela kwimveliso ezenzekelayo ye-MDA kwi-homogenate yesibindi segundane. Impembelelo yokuthintela ingcono kwi-concentration ye-0.875 mg / ml, ifikelela kwi-23.63%; f. I-mogroside extract inokuthintela i-lipid peroxidation kwi-rat yesibindi yesibindi, inefuthe elikhuselayo kumonakalo wesibindi we-peroxidation owenziwe yi-Fe kunye ne-H2O2, kwaye inokunciphisa ukwenzeka kwe-erythrocyte hemolysis; I-Mogroside inokuthintela kakhulu ukuveliswa kwe-MDA kwi-mitochondria yesibindi, kwaye izinga layo lokuthintela liyenyuka ngokunyuka koxinzelelo.
(4) Ukomelezwa kokhuselo lomzimba:
Ukulawulwa komlomo we-mogroside ukuya kwisiqhelo kunye ne-cyclophosphamide (CTX) -iigundane ezigxininisiweyo azizange zibe nempembelelo ephawulekayo ekusebenzeni komzimba kweegundane eziqhelekileyo, kodwa kuphuculwe kakhulu i-macrophage phagocytosis kunye ne-T cell proliferation ye-CTX-suppressed mice. Oku kubonisa ukuba i-mogroside inesiphumo esithile esilungileyo sokulawula umsebenzi weselula we-CTX-icinezelwe.
(5) Ifuthe kwiswekile yegazi:
Ukulawulwa komlomo omnye we-30% mogroside 200 mg / kg yayingenayo impembelelo ebalulekileyo kumxholo weshukela wegazi kunye nomsebenzi we-enzyme yesibindi yabantu abadala abanempilo.MogrosideI-V i-sweetener ekhuselekileyo engachaphazeli umxholo weswekile yegazi kubantu abaqhelekileyo.
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(6) Isiphumo sokulwa nomhlaza:
Ukusebenzisa i-DMBA njengomqalisi kunye ne-TPA njenge-carcinogen, i-mouse skin-step-step-carcinogenicity experiment yenziwa; ukulibaziseka kwe-carcinogenicity ye-mogroside iyafana okanye yomelele kunaleyo ye-stevioside, ebonisa ukuba inesiphumo esichasene nomhlaza. Ngoko ke, i-mogroside ingasetyenziselwa njenge-arhente yokulwa nomhlaza.
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Ixesha lokuposa: Aug-23-2024
